Vapor, dust, and smoke exposure in relation to adult-onset asthma and chronic respiratory symptoms: the Singapore Chinese Health Study

Am J Epidemiol. 2006 Jun 15;163(12):1118-28. doi: 10.1093/aje/kwj144. Epub 2006 May 17.

Abstract

Occupational factors contribute to a significant fraction of respiratory disease and symptoms. The authors evaluated the role of occupational exposures in asthma, chronic bronchitis, and respiratory symptoms in the Singapore Chinese Health Study, a population-based cohort of adults aged 45-74 years at enrollment in 1993-1998. Information on occupations and occupational exposures was collected at enrollment for 52,325 subjects for whom respiratory outcomes were obtained via follow-up interviews in 1999-2004. Exposure to dusts from cotton, wood, metal, minerals, and/or asbestos was associated with nonchronic cough and/or phlegm (odds ratio (OR) = 1.19, 95% confidence interval (CI): 1.08, 1.30), chronic bronchitis (OR = 1.26, 95% CI: 1.01, 1.57), and adult-onset asthma (OR = 1.14, 95% CI: 1.00, 1.30). Cotton dust was the major contributor to respiratory symptoms. Vapor exposure from chemical solvents, dyes, cooling oils, paints, wood preservatives, and/or pesticides was associated with nonchronic cough or phlegm (OR = 1.14, 95% CI: 1.03, 1.27), chronic dry cough (OR = 1.55, 95% CI: 1.19, 2.01), and adult-onset asthma (OR = 1.34, 95% CI: 1.15, 1.56). Chemical solvents, cooling oils, and pesticides were the major contributors to respiratory symptoms. These data support the role of occupational exposures in the etiology of respiratory illness in a population-based cohort in Singapore with a low prevalence of atopic illness.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Air Pollutants, Occupational / adverse effects*
  • Asthma / epidemiology
  • Asthma / etiology*
  • Bronchitis / epidemiology
  • Bronchitis / etiology*
  • China / ethnology
  • Chronic Disease
  • Cohort Studies
  • Cough / epidemiology
  • Cough / etiology
  • Dust*
  • Female
  • Gases*
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Occupational Exposure*
  • Occupations
  • Pulmonary Disease, Chronic Obstructive / epidemiology
  • Pulmonary Disease, Chronic Obstructive / etiology
  • Singapore / epidemiology
  • Smoke*
  • Surveys and Questionnaires

Substances

  • Air Pollutants, Occupational
  • Dust
  • Gases
  • Smoke