The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease

Altern Ther Health Med. 2006 May-Jun;12(3):34-9.


Context: Other than weight reduction by dieting or physical activity, there are no well-documented medical treatments for fatty liver disease.

Objective: To evaluate the efficacy of the add-on Gynostemma pentaphyllum (GP) in research subjects with nonalcoholic fatty liver disease.

Design: A randomized, single-blind, controlled clinical trial.

Setting: Hospital-based clinic.

Patients: Fifty-six research subjects who were diagnosed with nonalcoholic fatty liver by abdominal ultrasound scanning.

Interventions: The treatment group and the control group followed a controlled diet for 2 months. After 2 months, the treatment group continued to diet and received 80 mL GP extraction for 4 months; the control group continued to diet and received a placebo capsule for 4 months.

Main outcome measures: Body mass index (BMI), biochemistry data, and fatty liver score were measured at baseline, at 2 months, and at 6 months.

Results: After 2 months of dieting, BMI and most biochemistry data decreased in both study groups. There were no significant differences in BMI or biochemistry data at month 2 between the 2 study groups. At month 6, BMI, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase, alkaline phosphatase, insulin (ALP), insulin resistance index (HOMA-IR), and fatty liver score were reduced in both groups. The treatment group saw significant reductions in BMI, AST, ALP, insulin, and HOMA-IR, however. Changes in uric acid levels in the 2 groups from month 2 to month 6 were statistically significant (P = .028)

Conclusion: GP is an effective adjunct treatment to diet therapy for patients with nonalcoholic fatty liver disease.

Publication types

  • Controlled Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index
  • Dose-Response Relationship, Drug
  • Fatty Liver / drug therapy*
  • Fatty Liver / pathology
  • Female
  • Gynostemma*
  • Humans
  • Hypolipidemic Agents / administration & dosage*
  • Male
  • Middle Aged
  • Phytotherapy*
  • Plant Extracts / administration & dosage*
  • Single-Blind Method
  • Treatment Outcome
  • Weight Loss


  • Hypolipidemic Agents
  • Plant Extracts