Mercury elimination with oral DMPS, DMSA, vitamin C, and glutathione: an observational clinical review

Altern Ther Health Med. May-Jun 2006;12(3):70-5.


Tissue mercury levels in humans have increased during the past 50 years to an alarming concentration, with possible deleterious effects that may involve neurological, cardiovascular, and immunological pathology. This article reviews the protocol for the use of oral 2,3-dimercaptopropane-1-sulfonate (DMPS) and oral meso-2, 3-dimercaptosuccinic acid (DMSA) in combination with intravenous glutathione and high-dose vitamin C for treatment of high-level mercury. This protocol yielded an average 69% reduction of urine mercury by provocation analysis.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Ascorbic Acid / therapeutic use*
  • Chelating Agents / therapeutic use*
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Glutathione / therapeutic use*
  • Humans
  • Kidney / metabolism
  • Male
  • Mercury / pharmacokinetics*
  • Mercury / urine
  • Mercury Poisoning / drug therapy*
  • Middle Aged
  • Succimer / therapeutic use*
  • Treatment Outcome
  • Unithiol / therapeutic use*


  • Chelating Agents
  • Unithiol
  • Succimer
  • Mercury
  • Glutathione
  • Ascorbic Acid