Convection-enhanced delivery of immunotoxins and radioisotopes for treatment of malignant gliomas

Neurosurg Focus. 2006 Apr 15;20(4):E13. doi: 10.3171/foc.2006.20.4.8.


The treatment of malignant gliomas has advanced significantly in the past 15 years. The simultaneous development of new targeting agents and techniques to deliver these high-molecular-weight compounds has led to improved efficacy and promising results in Phase III trials. Convection-enhanced delivery (CED) of macromolecules has emerged as the leading delivery technique for the treatment of malignant gliomas. A summary of the basic principles of CED and a review of the current human trials of protein targeting agents are provided.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood-Brain Barrier / drug effects
  • Blood-Brain Barrier / metabolism
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / radiotherapy*
  • Combined Modality Therapy / methods
  • Combined Modality Therapy / trends
  • Drug Delivery Systems / methods
  • Drug Delivery Systems / trends
  • Glioma / drug therapy*
  • Glioma / radiotherapy*
  • Humans
  • Immunotoxins / administration & dosage*
  • Infusion Pumps / trends
  • Radioisotopes / administration & dosage*


  • Immunotoxins
  • Radioisotopes