Tubulo-interstitial nephritis and uveitis syndrome in a 6-year-old boy: case report

Ann Trop Paediatr. 2006 Jun;26(2):145-8. doi: 10.1179/146532806X107502.


A 6-year-old boy presented with a 4-month history of anorexia, weight loss and fatigue and was found to have tubulo-interstitial nephritis and uveitis (TINU) syndrome. After 2 months of corticosteroid therapy, resolution of the uveitis was almost complete but renal function showed only partial improvement. He was still in renal failure 6 months after diagnosis, but there was no relapse of the uveitis. Although the prognosis of TINU in children and adults is reported to be excellent, the outcome in young children can be less favourable, probably owing to delayed diagnosis and initiation of treatment.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / drug therapy
  • Acute Kidney Injury / etiology
  • Adrenal Cortex Hormones / therapeutic use
  • Anorexia / etiology
  • Child
  • Fatigue / etiology
  • Humans
  • Male
  • Nephritis, Interstitial / complications*
  • Nephritis, Interstitial / drug therapy
  • Prednisolone / therapeutic use
  • Prednisone / therapeutic use
  • Prognosis
  • Treatment Outcome
  • Uveitis / complications*
  • Uveitis / drug therapy
  • Weight Loss


  • Adrenal Cortex Hormones
  • Prednisolone
  • Prednisone