The interaction of bacterial pathogens with platelets

Nat Rev Microbiol. 2006 Jun;4(6):445-57. doi: 10.1038/nrmicro1425.


In recent years, the frequency of serious cardiovascular infections such as endocarditis has increased, particularly in association with nosocomially acquired antibiotic-resistant pathogens. Growing evidence suggests a crucial role for the interaction of bacteria with human platelets in the pathogenesis of cardiovascular infections. Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Platelets / microbiology*
  • Blood Platelets / physiology
  • Borrelia burgdorferi / physiology
  • Cardiovascular Diseases / microbiology*
  • Cardiovascular Diseases / physiopathology*
  • Cross Infection / microbiology
  • Cross Infection / physiopathology
  • Endocarditis, Bacterial / microbiology
  • Endocarditis, Bacterial / physiopathology
  • Helicobacter pylori / physiology
  • Humans
  • Platelet Activation / physiology*
  • Porphyromonas gingivalis / physiology
  • Staphylococcus aureus / physiology
  • Streptococcus / physiology