The exosome and the proteasome: nano-compartments for degradation

Esben Lorentzen; Elena Conti

doi:10.1016/j.cell.2006.05.002

The exosome and the proteasome: nano-compartments for degradation

Cell. 2006 May 19;125(4):651-4. doi: 10.1016/j.cell.2006.05.002.

Authors

Esben Lorentzen¹, Elena Conti

Affiliation

¹ European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

PMID: 16713559
DOI: 10.1016/j.cell.2006.05.002

Abstract

Exosomes and proteasomes are macromolecular complexes that posttranscriptionally regulate gene expression by degrading mRNAs and proteins, respectively. Although the two complexes act on different substrates and are composed of different subunits, they share a similar barrel-like architecture that appears to have evolved to restrict substrate access and prevent indiscriminate degradation.

Publication types

Review

MeSH terms

Binding Sites
Exoribonucleases / chemistry
Exoribonucleases / metabolism*
Macromolecular Substances
Proteasome Endopeptidase Complex / chemistry
Proteasome Endopeptidase Complex / metabolism*
Protein Conformation
Protein Subunits / chemistry
Protein Subunits / metabolism
RNA / metabolism*
Substrate Specificity

Substances

Macromolecular Substances
Protein Subunits
RNA
Exoribonucleases
Proteasome Endopeptidase Complex