The exosome and the proteasome: nano-compartments for degradation

Cell. 2006 May 19;125(4):651-4. doi: 10.1016/j.cell.2006.05.002.


Exosomes and proteasomes are macromolecular complexes that posttranscriptionally regulate gene expression by degrading mRNAs and proteins, respectively. Although the two complexes act on different substrates and are composed of different subunits, they share a similar barrel-like architecture that appears to have evolved to restrict substrate access and prevent indiscriminate degradation.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • Exoribonucleases / chemistry
  • Exoribonucleases / metabolism*
  • Macromolecular Substances
  • Proteasome Endopeptidase Complex / chemistry
  • Proteasome Endopeptidase Complex / metabolism*
  • Protein Conformation
  • Protein Subunits / chemistry
  • Protein Subunits / metabolism
  • RNA / metabolism*
  • Substrate Specificity


  • Macromolecular Substances
  • Protein Subunits
  • RNA
  • Exoribonucleases
  • Proteasome Endopeptidase Complex