Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T

Neurobiol Aging. 2007 May;28(5):719-26. doi: 10.1016/j.neurobiolaging.2006.03.007. Epub 2006 May 19.


Histological studies suggest that hippocampal subfields are differently affected by aging and Alzheimer's disease (AD). The aims of this study were: (1) To test if hippocampal subfields can be identified and marked using anatomical landmarks on high resolution MR images obtained on a 4T magnet. (2) To test if age-specific volume changes of subfields can be detected. Forty-two healthy controls (21-85 years) and three AD subjects (76-86 years) were studied with a high resolution T2 weighted fast spin echo sequence. The entorhinal cortex (ERC), subiculum, CA1, CA2 and CA3/4 and dentate were marked. A significant correlation between age and CA1 (r=-0.51, p=0.0002) which was most pronounced in the seventh decade of life was found in healthy controls. In AD subjects, CA1 and subiculum were smaller than in age-matched controls. These preliminary findings suggest that measurement of hippocampal subfields may be helpful to distinguish between normal aging and AD.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Aging / pathology
  • Aging / psychology
  • Female
  • Hippocampus / metabolism*
  • Hippocampus / pathology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Male
  • Memory / physiology
  • Middle Aged
  • Neuropsychological Tests