The role of androgens in the late-premenopausal woman with adenomatous hyperplasia of the endometrium

Int J Gynaecol Obstet. 1991 Feb;34(2):157-61. doi: 10.1016/0020-7292(91)90231-s.


To examine the possible role of androgens in hyperplasia of the endometrium, the concentrations of testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH), were measured in peripheral venous serum obtained from 42 premenopausal women with adenomatous hyperplasia of the endometrium (group A) and from 18 women without hyperplasia (group B). In patients with hyperplasia of the endometrium, significantly higher peripheral venous concentrations were found for all androgens (P less than 0.05) and estradiol (P less than 0.001) than in control patients. In contrast, there was no statistically significant difference in the mean serum values of SHBG as well as in gonadotropins among the population of compared groups. We conclude that apart from the increased estrogenic activity in patients with adenomatous hyperplasia of the endometrium, androgens may play a significant role.

Publication types

  • Comparative Study

MeSH terms

  • Androgens / blood
  • Androgens / physiology*
  • Endometrial Hyperplasia / blood
  • Endometrial Hyperplasia / etiology*
  • Estradiol / blood
  • Female
  • Follicle Stimulating Hormone / blood
  • Humans
  • Luteinizing Hormone / blood
  • Menopause
  • Middle Aged
  • Sex Hormone-Binding Globulin / analysis


  • Androgens
  • Sex Hormone-Binding Globulin
  • Estradiol
  • Luteinizing Hormone
  • Follicle Stimulating Hormone