Aging and innate immunity

Immunity. 2006 May;24(5):491-4. doi: 10.1016/j.immuni.2006.05.003.


Adaptive immunity undergoes severe deterioration with age and represents the main problem in the elderly. However, evidence accumulated over the last decade supports the hypothesis that aging also has a profound impact on innate immunity, which in turn markedly impacts the health and longevity of older people.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / immunology*
  • Humans
  • Immunity, Innate*
  • Signal Transduction / immunology*