Aging of the immune system: how much can the adaptive immune system adapt?

Immunity. 2006 May;24(5):495-9. doi: 10.1016/j.immuni.2006.05.001.


The competency of the adaptive immune function decreases with age, primarily because of the decline in production of naive lymphocytes in the bone marrow and thymus as well as the expansion of incompetent memory lymphocytes. Here I discuss the recent progress on age-associated changes in lymphocytes and their effect on the adaptive immune system.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / immunology*
  • Humans
  • Immune System / physiology
  • Immunity / physiology*
  • Immunologic Memory / physiology
  • Lymphocytes / immunology*