DNA architecture: from G to Z

Curr Opin Struct Biol. 2006 Jun;16(3):288-98. doi: 10.1016/j.sbi.2006.05.011. Epub 2006 May 22.


G-quadruplexes and Z-DNA are two important non-B forms of DNA architecture. Results on novel structural elements, folding and unfolding kinetics, and interactions with small molecules and proteins have been reported recently for these forms. These results will enhance our understanding of the biology of these structures and provide a platform for drug design.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • DNA / chemistry*
  • DNA / metabolism
  • DNA, Z-Form / chemistry
  • Models, Molecular*
  • Nucleic Acid Conformation
  • Nucleic Acid Heteroduplexes


  • DNA, Z-Form
  • Nucleic Acid Heteroduplexes
  • DNA