Lipase catalyzed synthesis of benzyl acetate in solvent-free medium using vinyl acetate as acyl donor

Abir B Majumder; Bhupender Singh; Debjit Dutta; Sushabhan Sadhukhan; Munishwar N Gupta

doi:10.1016/j.bmcl.2006.05.006

Lipase catalyzed synthesis of benzyl acetate in solvent-free medium using vinyl acetate as acyl donor

Bioorg Med Chem Lett. 2006 Aug 1;16(15):4041-4. doi: 10.1016/j.bmcl.2006.05.006. Epub 2006 May 22.

Authors

Abir B Majumder¹, Bhupender Singh, Debjit Dutta, Sushabhan Sadhukhan, Munishwar N Gupta

Affiliation

¹ Department of Chemistry, Indian Institute of Technology, Delhi, Hauz Khas, New Delhi 110016, India.

PMID: 16714111
DOI: 10.1016/j.bmcl.2006.05.006

Abstract

Use of vinyl acetate as acyl donor in transesterification of benzyl alcohol catalyzed by a commercially available lipase (Lipozyme RM IM) gave 100% conversion in 10 min. The excess acyl donor and the enzyme could be recovered and reused. Unlike the chemical catalytic processes, it produced no undesirable side product.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzyl Compounds / chemical synthesis*
Catalysis
Lipase / metabolism*
Magnetic Resonance Spectroscopy
Solvents / chemistry*
Spectrophotometry, Infrared
Vinyl Compounds / chemistry*

Substances

Benzyl Compounds
Solvents
Vinyl Compounds
benzyl acetate
Lipase
vinyl acetate