Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles

Shu-Ting Huang; I-Jen Hsei; Chinpiao Chen

doi:10.1016/j.bmc.2006.05.007

Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles

Bioorg Med Chem. 2006 Sep 1;14(17):6106-19. doi: 10.1016/j.bmc.2006.05.007. Epub 2006 May 22.

Authors

Shu-Ting Huang¹, I-Jen Hsei, Chinpiao Chen

Affiliation

¹ Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan.

PMID: 16714116
DOI: 10.1016/j.bmc.2006.05.007

Abstract

Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 microM), A-549 cells (IC50 6.6 microM), and MES-SA cells (IC50 9.2 microM), respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzimidazoles / chemical synthesis*
Benzimidazoles / chemistry
Benzimidazoles / pharmacology*
Benzothiazoles / chemical synthesis*
Benzothiazoles / chemistry
Benzothiazoles / pharmacology*
Benzoxazoles / chemical synthesis*
Benzoxazoles / chemistry
Benzoxazoles / pharmacology*
Cell Line, Tumor
Humans
Molecular Structure
Neoplasms / drug therapy
Neoplasms / pathology*

Substances

Benzimidazoles
Benzothiazoles
Benzoxazoles