Fitness of antimicrobial-resistant Campylobacter and Salmonella

Microbes Infect. 2006 Jun;8(7):1972-8. doi: 10.1016/j.micinf.2005.12.031. Epub 2006 Mar 31.


Campylobacter and Salmonella are the most commonly reported bacterial causes of human foodborne infections, and increasing proportions of these pathogens become resistant to medically important antimicrobial agents, imposing a burden on public health. Acquisition of resistance to antibiotics affects the adaptation and evolution of Salmonella and Campylobacter in various environments. Many resistance-conferring mutations entail a biological fitness cost, while others (e.g. fluoroquinolone resistance in Campylobacter) have no cost or even enhanced fitness. In Salmonella, the fitness disadvantage due to antimicrobial resistance can be restored by acquired compensatory mutations, which occur both in vitro and in vivo. The compensated or even enhanced fitness associated with antibiotic resistance may facilitate the spread and persistence of antimicrobial-resistant Salmonella and Campylobacter in the absence of selection pressure, creating a significant barrier for controlling antibiotic-resistant foodborne pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Campylobacter / drug effects*
  • Campylobacter / genetics
  • Campylobacter / physiology*
  • Campylobacter Infections / microbiology
  • Drug Resistance, Bacterial*
  • Humans
  • Mutation
  • Salmonella / drug effects*
  • Salmonella / genetics
  • Salmonella / physiology*
  • Salmonella Infections / microbiology