Dual Antagonists of Platelet Activating Factor and Histamine. Identification of Structural Requirements for Dual Activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines

J Med Chem. 1991 Jan;34(1):457-61. doi: 10.1021/jm00105a069.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Guinea Pigs
  • Histamine H1 Antagonists / chemical synthesis*
  • Indicators and Reagents
  • Lung / drug effects
  • Lung / physiology
  • Molecular Structure
  • Piperidines / chemical synthesis*
  • Piperidines / chemistry
  • Piperidines / pharmacology
  • Platelet Activating Factor / antagonists & inhibitors*
  • Receptors, Histamine H1 / drug effects
  • Receptors, Histamine H1 / metabolism
  • Structure-Activity Relationship

Substances

  • Histamine H1 Antagonists
  • Indicators and Reagents
  • Piperidines
  • Platelet Activating Factor
  • Receptors, Histamine H1