High-dose intravenous IgG treatment and renal function

Lancet. 1991 Feb 23;337(8739):457-8. doi: 10.1016/0140-6736(91)93395-p.


In an open trial of high dose intravenous IgG (IVIG) treatment in nephrotic patients with glomerulonephritis, the first six patients so far studied showed a transient rise in plasma creatinine. This increase was not associated with any symptoms and the urinary deposit remained unchanged. Two other patients with pre-existing renal impairment but without nephrotic syndrome had a transient and reversible rise in plasma creatinine immediately after IVIG. These observations suggest that high-dose IVIG infusion can produce short-lived disturbances in renal function in patients with kidney diseases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Creatinine / blood*
  • Drug Administration Schedule
  • Drug Evaluation
  • Female
  • Glomerulonephritis / blood
  • Glomerulonephritis / drug therapy*
  • Hemophilia A / blood
  • Hemophilia A / drug therapy
  • Humans
  • Immunoglobulin G / administration & dosage*
  • Immunoglobulin G / therapeutic use
  • Immunoglobulins, Intravenous
  • Infusions, Intravenous
  • Male
  • Purpura, Thrombocytopenic / blood
  • Purpura, Thrombocytopenic / drug therapy


  • Immunoglobulin G
  • Immunoglobulins, Intravenous
  • Creatinine