B-type natriuretic peptide levels in patients with paroxysmal lone atrial fibrillation

Heart Vessels. 2006 May;21(3):137-40. doi: 10.1007/s00380-005-0884-y.


To investigate the levels of B-type natriuretic peptide (BNP) in patients with atrial fibrillation (AF) but without structural heart disease, we measured plasma BNP concentration in 61 consecutive AF patients and in 61 age- and sex-matched healthy subjects. Plasma BNP concentration in the AF group was significantly higher than in the control group (121+/-32 vs 41+/-12 pg/ml, P<0.001). Logistic regression analysis showed that age (r=0.66, P<0.001), left atrial diameter (r=0.59, P<0.01), and a history of AF (r=0.72, P<0.001) were independent predictors of elevated BNP. We concluded that BNP was elevated in patients with paroxysmal lone AF. The clinical significance of BNP elevation in these patients requires further investigation.

MeSH terms

  • Adult
  • Aged
  • Atrial Fibrillation / blood*
  • Atrial Fibrillation / drug therapy
  • Atrial Fibrillation / pathology
  • Atrial Fibrillation / physiopathology
  • Female
  • Heart Atria / pathology
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood*
  • Ventricular Function, Left


  • Natriuretic Peptide, Brain