Intrahepatic cholangiocarcinoma with lymph node metastasis successfully treated by immunotherapy with CD3-activated T cells and dendritic cells after surgery: report of a case

Surg Today. 2006;36(6):559-62. doi: 10.1007/s00595-006-3201-1.


Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tumor lysate- or peptide-pulsed dendritic cells. Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion. The patient has been alive without recurrence for 3 years 6 months since her operation.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / surgery
  • Adenocarcinoma / therapy*
  • Bile Duct Neoplasms / surgery
  • Bile Duct Neoplasms / therapy*
  • Bile Ducts, Intrahepatic*
  • CD3 Complex / immunology*
  • Cholangiocarcinoma / surgery
  • Cholangiocarcinoma / therapy*
  • Combined Modality Therapy
  • Dendritic Cells / immunology*
  • Female
  • Humans
  • Immunotherapy / methods*
  • Lymphatic Metastasis
  • Lymphocyte Activation
  • Middle Aged
  • T-Lymphocytes / immunology*


  • CD3 Complex