Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings

Ann Nucl Med. 2006 Apr;20(3):233-6. doi: 10.1007/BF03027436.

Abstract

Diaphyseal medullary stenosis (DMS) is an extremely rare hereditary bone dysplasia, which was first described by Arnold in 1973. DMS has a high incidence of pleomorphic malignant fibrous histiocytoma (MFH). In this paper, we report the imaging findings of DMS with pleomorphic MFH of the bone, mainly describing 99mTc hydroxymethylenediphosphonate (HMDP) and thallium-201 (201Tl) chloride scintigraphy findings. On 99mTc HMDP scintigraphy, focal increased uptake area of the right femur corresponded to the area of bone marrow invasion of the tumor and bone infarction. The mechanism of the uptake of 99mTc HMDP to the extraosseous lesion was not clear. On 201Tl chloride scintigraphy, the increased uptake of the periphery of the mass seemed to reflect the aggressiveness of invasion and the cellularity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Neoplasms / diagnostic imaging*
  • Camurati-Engelmann Syndrome / complications
  • Camurati-Engelmann Syndrome / diagnostic imaging*
  • Histiocytoma, Malignant Fibrous / complications
  • Histiocytoma, Malignant Fibrous / diagnostic imaging*
  • Humans
  • Male
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate / analogs & derivatives*
  • Thallium*

Substances

  • Radiopharmaceuticals
  • thallium chloride
  • technetium Tc 99m hydroxymethylene diphosphonate
  • Thallium
  • Technetium Tc 99m Medronate