Regulation of angiogenesis by hypoxia-inducible factor 1

Crit Rev Oncol Hematol. 2006 Jul;59(1):15-26. doi: 10.1016/j.critrevonc.2005.12.003. Epub 2006 May 22.


Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified as the transcription factor that mediates hypoxia-induced erythropoietin expression. More recently, the delineation of molecular mechanisms of angiogenesis has revealed a critical role for HIF-1 in the regulation of angiogenic growth factors. In this review, we discuss the role of HIF-1 in developmental, adaptive and pathological angiogenesis. In addition, potential therapeutic interventions involving modulation of HIF-1 activity in ischemic cardiovascular disease and cancer will be discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / physiology
  • Humans
  • Hypoxia-Inducible Factor 1 / physiology*
  • Hypoxia-Inducible Factor 1 / therapeutic use
  • Neovascularization, Pathologic* / prevention & control
  • Neovascularization, Physiologic / physiology*
  • Transcription, Genetic / physiology


  • Hypoxia-Inducible Factor 1