Management of malignant pleural mesothelioma

Clin Chest Med. 2006 Jun;27(2):335-54. doi: 10.1016/j.ccm.2006.01.004.


Malignant mesothelioma is increasing in incidence globally and has no known cure. Its unique clinical feature of local infiltration along tissue planes makes it a difficult neoplasm to manage. There have been few randomized controlled trials regarding treatment options, although these have increased in recent years, and results are eagerly awaited. This article summarizes important advances in the management of mesothelioma, especially diagnostic and therapeutic aspects.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Combined Modality Therapy
  • Genetic Predisposition to Disease
  • Humans
  • Magnetic Resonance Imaging
  • Mesothelioma / diagnosis*
  • Mesothelioma / genetics
  • Mesothelioma / pathology
  • Mesothelioma / therapy*
  • Neoplasm Staging
  • Photochemotherapy
  • Pleural Neoplasms / diagnosis*
  • Pleural Neoplasms / genetics
  • Pleural Neoplasms / pathology
  • Pleural Neoplasms / therapy*
  • Positron-Emission Tomography
  • Prognosis
  • Thoracoscopy