Calcium crystal deposition and osteoarthritis

Rheum Dis Clin North Am. 2006 May;32(2):401-12, vii. doi: 10.1016/j.rdc.2006.02.004.


Calcium crystals are common and under-recognized participants in osteoarthritis. Excellent evidence supports two hypotheses explaining the relationship between calcium crystal deposition and osteoarthritis. There is ample support for the theory that calcium crystals cause or worsen osteoarthritis and equally compelling evidence to support the theory that osteoarthritis causes or worsens calcium crystal formation. Further research in this area will improve understanding of the pathogenesis of these conditions and should lead to the development of effective therapy for all types of degenerative arthritis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Calcium Phosphates / metabolism*
  • Calcium Pyrophosphate / metabolism*
  • Crystallization
  • Humans
  • Osteoarthritis / etiology
  • Osteoarthritis / metabolism*
  • Synovial Fluid / chemistry


  • Calcium Phosphates
  • calcium phosphate
  • Calcium Pyrophosphate