Predictive value of S-100B protein and neuron specific-enolase as markers of traumatic brain damage in clinical use

Brain Inj. 2006 May;20(5):463-8. doi: 10.1080/02699050600664418.


Objective: S-100B and NSE proteins are considered to be neurobiochemical markers for the brain damage. The aim of this study was to consider the diagnostic and prognostic validity of the initial serum levels of S-100B and NSE in clinical use.

Methods: Forty-five patients with traumatic brain injury were included in this prospective study. Neurologic examination and CCT-scan were performed. S-100B and NSE were analysed. Patients were divided in two groups depending on the severity of injury.

Results: The results showed a significant difference between the S-100B serum concentration and the two groups-minor head injuries and severe head injuries. A statistically significant correlation was observed between an increase of S-100B and NSE serum values and a cerebral pathological finding in CT scans.

Conclusion: The clear correlation between S-100B and NSE serum concentrations and CCT findings does not validate both markers as an independent predictor of diagnosis and prognosis of brain injury.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / analysis
  • Brain Injuries / blood*
  • Brain Injuries / diagnosis
  • Female
  • Glasgow Coma Scale
  • Humans
  • Male
  • Middle Aged
  • Nerve Growth Factors / blood*
  • Phosphopyruvate Hydratase / blood*
  • Predictive Value of Tests
  • Prospective Studies
  • Reproducibility of Results
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins / blood*
  • Tomography, X-Ray Computed


  • Biomarkers
  • Nerve Growth Factors
  • S100 Calcium Binding Protein beta Subunit
  • S100 Proteins
  • Phosphopyruvate Hydratase