Effects of itopride hydrochloride on plasma gut-regulatory peptide and stress-related hormone levels in healthy human subjects

Pharmacology. 2006;77(3):115-21. doi: 10.1159/000093485. Epub 2006 May 22.


Itopride hydrochloride (itopride), a gastrokinetic drug, has recently been evaluated for its clinical usefulness in functional dyspepsia. We investigated effects of itopride on human plasma gastrin-, somatostatin-, motilin-, and cholecystokinin (CCK)-like immunoreactive substances (IS); adrenocorticotropic hormone (ACTH)-immunoreactive substances (IS), and cortisol under stress conditions in healthy subjects. A single administration of itopride caused significant increases in plasma somatostatin- and motilin-IS levels compared to placebo. Itopride significantly decreased plasma CCK-IS, and suppressed the ACTH-IS level compared to placebo. We hypothesize that itopride may have an accelerating gastric emptying effect, and a modulatory effect on the hypothalamo-pituitary-adrenal axis and autonomic nervous functions. These effects might be beneficial in stress-related diseases, suggesting that itopride has clinicopharmacological activities.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adrenocorticotropic Hormone / blood*
  • Adult
  • Benzamides / blood
  • Benzamides / pharmacokinetics
  • Benzamides / pharmacology*
  • Benzyl Compounds / blood
  • Benzyl Compounds / pharmacokinetics
  • Benzyl Compounds / pharmacology*
  • Cholecystokinin / blood*
  • Gastrins / blood
  • Gastrointestinal Agents / blood
  • Gastrointestinal Agents / pharmacokinetics
  • Gastrointestinal Agents / pharmacology
  • Humans
  • Hydrocortisone / blood
  • Male
  • Motilin / blood*
  • Somatostatin / blood*


  • Benzamides
  • Benzyl Compounds
  • Gastrins
  • Gastrointestinal Agents
  • Somatostatin
  • Motilin
  • itopride
  • Adrenocorticotropic Hormone
  • Cholecystokinin
  • Hydrocortisone