Performance on spatial working memory tasks after dorsal or ventral hippocampal lesions and adjacent damage to the subiculum

Behav Neurosci. 2006 Apr;120(2):413-22. doi: 10.1037/0735-7044.120.2.413.


Rats with excitotoxic lesions of the dorsal or ventral hippocampus and control rats were trained on 2 spatial working memory tasks: the standard version of the radial maze with 8 baited arms and the non-matching-to-place procedure in the T maze. Dorsal lesions produced deficits in both tasks, whereas ventral lesions did not affect learning in either of them. A volumetric analysis of subicular damage showed that dorsal hippocampal lesions caused a deficit in the non-matching-to-place only when accompanied by damage to the dorsal subiculum; on the other hand, lesions to the dorsal hippocampus impaired performance in the radial-arm maze regardless of the extent of subicular damage.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Behavior, Animal
  • Brain Injuries / chemically induced
  • Brain Injuries / physiopathology*
  • Excitatory Amino Acid Agonists / toxicity
  • Hippocampus / pathology*
  • Hippocampus / physiopathology*
  • Linear Models
  • Male
  • Maze Learning / drug effects
  • Memory, Short-Term / drug effects
  • Memory, Short-Term / physiology*
  • N-Methylaspartate / toxicity
  • Rats
  • Rats, Long-Evans
  • Space Perception / drug effects
  • Space Perception / physiology*


  • Excitatory Amino Acid Agonists
  • N-Methylaspartate