Repressed expression of the HER-2/c-erbB-2 proto-oncogene by the adenovirus E1a gene products

Oncogene. 1991 Feb;6(2):343-5.


The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsible for the repression of HER-2/c-erbB-2 at the RNA level.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenovirus Early Proteins
  • Breast Neoplasms / genetics
  • Down-Regulation
  • Female
  • Humans
  • Oncogene Proteins, Viral / genetics*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • RNA, Messenger / analysis
  • Receptor, ErbB-2
  • Tumor Cells, Cultured


  • Adenovirus Early Proteins
  • Oncogene Proteins, Viral
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Receptor, ErbB-2