SNPStats: a web tool for the analysis of association studies

Bioinformatics. 2006 Aug 1;22(15):1928-9. doi: 10.1093/bioinformatics/btl268. Epub 2006 May 23.


Summary: A web-based application has been designed from a genetic epidemiology point of view to analyze association studies. Main capabilities include descriptive analysis, test for Hardy-Weinberg equilibrium and linkage disequilibrium. Analysis of association is based on linear or logistic regression according to the response variable (quantitative or binary disease status, respectively). Analysis of single SNPs: multiple inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive), and analysis of interactions (gene-gene or gene-environment). Analysis of multiple SNPs: haplotype frequency estimation, analysis of association of haplotypes with the response, including analysis of interactions.

Availability: Source code for local installation is available under GNU license.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping / methods*
  • Computer Simulation
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetics, Population*
  • Internet*
  • Models, Genetic*
  • Models, Statistical
  • Polymorphism, Single Nucleotide / genetics*
  • Software*


  • Genetic Markers