Abstract
Cerebral blood flow (CBF) was assessed during a verbal recall task using [(15)O]water positron emission tomography (PET) in older adults with mild cognitive deficits participating in a placebo-controlled donepezil trial. The placebo group demonstrated reduced CBF in the left frontal and temporal regions over the 6-month period, while those receiving donepezil did not. The placebo group's performance did not change on a list-learning task, while the donepezil group's performance improved, despite having had lower performance at intake. These findings suggest that donepezil treatment may be associated with a relative maintenance of CBF and improved list-learning.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
MeSH terms
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Activities of Daily Living / classification
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Aged
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Aged, 80 and over
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Blood Flow Velocity / drug effects
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Brain / blood supply*
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Brain / diagnostic imaging
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Cerebral Cortex / blood supply
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Cerebral Cortex / diagnostic imaging
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Cognition Disorders / diagnostic imaging*
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Cognition Disorders / drug therapy*
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Dominance, Cerebral / physiology
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Donepezil
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Double-Blind Method
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Female
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Humans
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Image Processing, Computer-Assisted
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Indans / therapeutic use*
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Magnetic Resonance Imaging
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Male
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Mental Status Schedule
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Middle Aged
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Neuropsychological Tests
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Nootropic Agents / therapeutic use*
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Piperidines / therapeutic use*
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Positron-Emission Tomography*
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Regional Blood Flow / drug effects
Substances
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Indans
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Nootropic Agents
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Piperidines
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Donepezil