Topical calcipotriol treatment in advanced breast cancer

Lancet. 1991 Mar 23;337(8743):701-2. doi: 10.1016/0140-6736(91)90280-3.

Abstract

19 patients with locally advanced or cutaneous metastatic breast cancer were treated with the topical vitamin D analogue calcipotriol 100 micrograms daily. 14 patients completed 6 weeks' treatment; 3 showed a 50% reduction in the bidimensional diameter of treated lesions and 1 other patient showed a minimal response. 2 patients became hypercalcaemic during treatment. In all patients who responded the tumours contained receptors for 1,25-dihydroxyvitamin D3, shown by immunocytochemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology
  • Calcitriol / administration & dosage
  • Calcitriol / adverse effects
  • Calcitriol / analogs & derivatives*
  • Calcitriol / therapeutic use
  • Carcinoma / drug therapy*
  • Carcinoma / secondary
  • Drug Administration Schedule
  • Drug Evaluation
  • Female
  • Humans
  • Hypercalcemia / chemically induced
  • Middle Aged
  • Receptors, Calcitriol
  • Receptors, Estrogen / drug effects
  • Receptors, Steroid / drug effects
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / secondary

Substances

  • Receptors, Calcitriol
  • Receptors, Estrogen
  • Receptors, Steroid
  • calcipotriene
  • Calcitriol