The long term prognostic significance of c-erbB-2 in primary breast cancer

Br J Cancer. 1991 Mar;63(3):447-50. doi: 10.1038/bjc.1991.103.


The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

MeSH terms

  • Breast Neoplasms / chemistry*
  • Breast Neoplasms / mortality
  • Breast Neoplasms / pathology
  • Female
  • Humans
  • Lymphatic Metastasis
  • Prognosis
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogenes*
  • Receptor, ErbB-2
  • Receptors, Estrogen / analysis
  • Survival


  • Proto-Oncogene Proteins
  • Receptors, Estrogen
  • Receptor, ErbB-2