Sintering and robocasting of beta-tricalcium phosphate scaffolds for orthopaedic applications

Acta Biomater. 2006 Jul;2(4):457-66. doi: 10.1016/j.actbio.2006.02.004. Epub 2006 May 24.


beta-Tricalcium phosphate (beta-TCP) scaffolds with designed, three-dimensional (3-D) geometry and mesoscale porosity have been fabricated by direct-write assembly (robocasting) techniques. Concentrated beta-TCP inks with suitable viscoelastic properties were developed to enable the fabrication of the complex 3-D structures. A comprehensive study of the sintering behavior of TCP as a function of the calcium content in the starting powder was also carried out, and the optimal heat treatment for fabricating scaffolds with dense beta-TCP rods has been determined. Such analysis provides clues to controlling the microstructure of the fabricated structures and, therefore, enabling the fabrication by robocasting of TCP scaffolds with tailored performance for bone tissue engineering applications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Biomedical Engineering*
  • Bone Substitutes / chemistry*
  • Calcium Phosphates / chemistry*
  • Chemistry, Bioinorganic / methods*
  • Manufactured Materials
  • Microscopy, Electron, Scanning
  • Porosity
  • Powders / chemistry
  • Viscosity


  • Biocompatible Materials
  • Bone Substitutes
  • Calcium Phosphates
  • Powders
  • beta-tricalcium phosphate