Risk factors for growth of unruptured intracranial aneurysms: follow-up study by serial 0.5-T magnetic resonance angiography

Neurosurgery. 2006 Jun;58(6):1047-53; discussion 1047-53. doi: 10.1227/01.NEU.0000217366.02567.D2.


Objective: The independent risk factors for aneurysm growth were retrospectively investigated in 130 patients with unruptured aneurysms who were followed up by 0.5-T serial magnetic resonance angiography with stereoscopic images.

Methods: Age, sex, site of aneurysm, size of aneurysm, multiplicity of aneurysms, type of circle of Willis, length of follow-up period, cerebrovascular event, hypertension, diabetes, hyperlipidemia, smoking habit, and family history of subarachnoid hemorrhage were investigated using multiple logistic analysis.

Results: Fourteen patients (16 aneurysms) among the 130 patients (159 aneurysms) showed aneurysm growth (10.8%) during follow-up of 10 to 69 months (mean 29.3 +/- 10.5 mo). Multiple logistic analysis disclosed that location on the middle cerebral artery (odds ratio [OR] 0.08, P < 0.01), multiplicity of aneurysms (OR 68.5, P < 0.01), aneurysm size of 5 mm or larger (OR 1.17, P = 0.05), and family history of subarachnoid hemorrhage (OR 10.9, P < 0.01) were independent risk factors.

Conclusion: Location on the middle cerebral artery, multiplicity, aneurysm size of 5 mm or larger, and family history of subarachnoid hemorrhage are independent risk factors for aneurysm growth. These results may help to determine the treatment choice for unruptured aneurysms.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Imaging, Three-Dimensional
  • Intracranial Aneurysm / diagnosis*
  • Intracranial Aneurysm / physiopathology*
  • Logistic Models
  • Magnetic Resonance Angiography*
  • Male
  • Medical Records
  • Middle Aged
  • Middle Cerebral Artery
  • Retrospective Studies
  • Risk Factors
  • Subarachnoid Hemorrhage / genetics