Harnessing actin dynamics for clathrin-mediated endocytosis

Nat Rev Mol Cell Biol. 2006 Jun;7(6):404-14. doi: 10.1038/nrm1940.


Actin polymerization often occurs at the plasma membrane to drive the protrusion of lamellipodia and filopodia at the leading edge of migrating cells. A role for actin polymerization in another cellular process that involves the reshaping of the plasma membrane--namely endocytosis--has recently been established. Live-cell imaging studies are shedding light on the order and timing of the molecular events and mechanisms of actin function during endocytosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cell Membrane / metabolism
  • Cell Movement
  • Clathrin / metabolism*
  • Endocytosis*
  • Pseudopodia / metabolism
  • Pseudopodia / physiology


  • Actins
  • Clathrin