Nuclear factor-kappaB in cancer development and progression

Nature. 2006 May 25;441(7092):431-6. doi: 10.1038/nature04870.


Nuclear factor-kappaB (NF-kappaB) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kappaB signalling also has a critical role in cancer development and progression. NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-kappaB might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Progression
  • Humans
  • Inflammation / drug therapy
  • Inflammation / metabolism
  • Inflammation / pathology
  • Inflammation / prevention & control
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism*
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Neoplasms / prevention & control
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology


  • NF-kappa B