CEACAM1: contact-dependent control of immunity

Nat Rev Immunol. 2006 Jun;6(6):433-46. doi: 10.1038/nri1864.


The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. Recent studies show that there is an important role for members of the CEACAM family in modulating the immune responses associated with infection, inflammation and cancer. In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, CD / biosynthesis
  • Antigens, CD / chemistry
  • Antigens, CD / physiology*
  • Cell Adhesion Molecules / biosynthesis
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / physiology*
  • Cell Communication / immunology*
  • Humans
  • Immunity, Cellular*
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / immunology*
  • Lymphoid Tissue / metabolism
  • Lymphoid Tissue / pathology
  • Myeloid Cells / cytology
  • Myeloid Cells / immunology*
  • Myeloid Cells / metabolism
  • Myeloid Cells / pathology


  • Antigens, CD
  • CD66 antigens
  • Cell Adhesion Molecules