Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus

Yasuhiro Igarashi; Shin-Suke Miura; Tsuyoshi Fujita; Tamotsu Furumai

doi:10.1038/ja.2006.28

Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus

J Antibiot (Tokyo). 2006 Mar;59(3):193-5. doi: 10.1038/ja.2006.28.

Authors

Yasuhiro Igarashi¹, Shin-Suke Miura, Tsuyoshi Fujita, Tamotsu Furumai

Affiliation

¹ Biotechnology Research Center, Toyama Prefectural University, Kurokawa, Kosugi, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp

PMID: 16724461
DOI: 10.1038/ja.2006.28

Abstract

A new cytotoxic compound, pterocidin, was isolated from the endophytic Streptomyces hygroscopicus TP-A0451, and the structure was determined on the basis of spectroscopic data. Pterocidin showed cytotoxicity against some human cancer cell lines with IC50 values of 2.9-7.1 microM.

MeSH terms

Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology
Cell Line, Tumor
Humans
Pyrones / chemistry
Pyrones / isolation & purification*
Pyrones / pharmacology
Streptomyces / metabolism*

Substances

Antibiotics, Antineoplastic
Pyrones
pterocidin