Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease

Curr Top Microbiol Immunol. 2006:305:51-66. doi: 10.1007/3-540-29714-6_3.


Naturally arising CD25+CD4+ regulatory T cells, which express the transcription factor Foxp3, play key roles in the maintenance of immunologic self-tolerance and negative control of a variety of physiological and pathological immune responses. The majority of them are produced by the normal thymus as a functionally mature T cell subpopulation specialized for suppressive function. Their generation is in part genetically and developmentally controlled. Genetically determined or environmentally induced abnormality in CD25+CD4+ regulatory T cell development, maintenance, and function can be a cause of autoimmune disease in humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD
  • Antigens, Differentiation / physiology
  • Autoimmune Diseases / etiology*
  • CTLA-4 Antigen
  • Forkhead Transcription Factors / analysis
  • Forkhead Transcription Factors / physiology*
  • Humans
  • Immune Tolerance*
  • Interleukin-2 / physiology
  • Polyendocrinopathies, Autoimmune / etiology
  • T-Lymphocytes, Regulatory / physiology*
  • Thymus Gland / immunology


  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Ctla4 protein, mouse
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Foxp3 protein, mouse
  • Interleukin-2