Cycloleonuripeptides E and F, cyclic nonapeptides from Leonurus heterophyllus

J Nat Prod. 2006 May;69(5):839-41. doi: 10.1021/np050544k.

Abstract

Two new cyclic nonapeptides, cycloleonuripeptide E, cyclo (-Ala-Pro-Ile-Val-Ala-Ala-Phe-Thr-Pro-), and cycloleonuripeptide F, cyclo (-Gly-Tyr-Pro-Leu-Pro-Phe-Tyr-Pro-Pro-), have been isolated from the fruits of Leonurus heterophyllus, and their structures were elucidated by 2D NMR analysis and chemical degradation. Cycloleonuripeptides E (1) and F (2) showed moderate vasorelaxant effects on rat aorta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Aorta / drug effects
  • Drugs, Chinese Herbal* / chemistry
  • Drugs, Chinese Herbal* / isolation & purification
  • Drugs, Chinese Herbal* / pharmacology
  • Fruit / chemistry
  • Lamiaceae / chemistry*
  • Male
  • Molecular Structure
  • Peptides, Cyclic* / chemistry
  • Peptides, Cyclic* / isolation & purification
  • Peptides, Cyclic* / pharmacology
  • Plant Proteins* / chemistry
  • Plant Proteins* / isolation & purification
  • Plant Proteins* / pharmacology
  • Plants, Medicinal / chemistry*
  • Rats
  • Rats, Wistar
  • Vasodilator Agents* / chemistry
  • Vasodilator Agents* / isolation & purification
  • Vasodilator Agents* / pharmacology

Substances

  • Drugs, Chinese Herbal
  • Peptides, Cyclic
  • Plant Proteins
  • Vasodilator Agents
  • cycloleonuripeptide E
  • cycloleonuripeptide F