Abstract
Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adipose Tissue, Brown / metabolism*
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Animals
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Biological Transport
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Carrier Proteins / physiology*
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Fatty Acids / metabolism*
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Ion Channel Gating
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Ion Channels
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Lipid Peroxidation
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Membrane Proteins / physiology*
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Mitochondrial Proteins
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Protons
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Purine Nucleotides / metabolism
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Uncoupling Protein 1
Substances
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Carrier Proteins
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Fatty Acids
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Ion Channels
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Membrane Proteins
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Mitochondrial Proteins
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Protons
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Purine Nucleotides
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Uncoupling Protein 1