Decreasing invasive pneumococcal disease in the elderly: a state-level analysis

Vaccine. 2006 Jul 7;24(27-28):5609-14. doi: 10.1016/j.vaccine.2006.04.055. Epub 2006 May 6.

Abstract

Evidence has accumulated supporting the relationship between the use of 7-valent pneumococcal conjugate vaccine (PCV7) in children and a decline in invasive pneumococcal disease (IPD) in the elderly. We conducted a state-level analysis of vaccination coverage rates among children 19-35 months of age and IPD hospitalization rates among elderly Medicare beneficiaries. Simple correlations were suggestive of a negative relationship. Multivariate analysis using a state fixed-effect model which helped control for the time invariant factors at the state level also indicated a negative relationship, and it was statistically significant, p = 0.035. The relationship between the use of 23-valent pneumococcal polysaccharide vaccine (PPV23) and IPD hospitalizations was not statistically significant using either method.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Child, Preschool
  • Female
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Hospitalization / statistics & numerical data
  • Humans
  • Infant
  • Influenza Vaccines / therapeutic use
  • Influenza, Human / epidemiology
  • Influenza, Human / prevention & control
  • Male
  • Meningococcal Vaccines / therapeutic use*
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / immunology
  • Pneumococcal Infections / prevention & control
  • Pneumococcal Vaccines / therapeutic use*
  • Regression Analysis
  • Streptococcus pneumoniae / immunology*
  • United States / epidemiology
  • Vaccination / statistics & numerical data

Substances

  • 23-valent pneumococcal capsular polysaccharide vaccine
  • Heptavalent Pneumococcal Conjugate Vaccine
  • Influenza Vaccines
  • Meningococcal Vaccines
  • Pneumococcal Vaccines