Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)

Science. 1991 Apr 5;252(5002):120-3. doi: 10.1126/science.1672777.


The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A and ANPR-B). Although atrial natriuretic peptide (ANP) and, to a lesser extent, brain natriuretic peptide (BNP) are efficient activators of the ANPR-A guanylyl cyclase, neither hormone can significantly stimulate ANPR-B. A member of this hormone family, C-type natriuretic peptide (CNP), potently and selectively activated the human ANPR-B guanylyl cyclase. CNP does not increase guanosine 3',5'-monophosphate accumulation in cells expressing human ANPR-A. The affinity of CNP for ANPR-B is 50- or 500-fold higher than ANP or BNP, respectively. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.

MeSH terms

  • Animals
  • Atrial Natriuretic Factor / physiology*
  • Cells, Cultured
  • Chlorocebus aethiops
  • Cloning, Molecular
  • Dose-Response Relationship, Drug
  • Guanylate Cyclase / metabolism
  • Humans
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Nerve Tissue Proteins / pharmacology*
  • Receptors, Atrial Natriuretic Factor
  • Receptors, Cell Surface / physiology*
  • Recombinant Proteins
  • Signal Transduction


  • Nerve Tissue Proteins
  • Receptors, Cell Surface
  • Recombinant Proteins
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Atrial Natriuretic Factor
  • Guanylate Cyclase
  • Receptors, Atrial Natriuretic Factor