Comparative genetics of MHC polymorphisms in different primate species: duplications and deletions

Hum Immunol. 2006 Jun;67(6):388-97. doi: 10.1016/j.humimm.2006.03.007. Epub 2006 Apr 3.


Gene products of the major histocompatibility complex (MHC) play a crucial role in the activation of adaptive (antigen-dependent) immune responses. In this paper similarities and dissimilarities among the MHCs of different primate species and their functional implications are reviewed. The human HLA system represents the most thoroughly investigated MHC of any contemporary living primate species, and so it will serve as a reference.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular
  • Gene Deletion
  • Gene Duplication
  • Genes, MHC Class I
  • Genes, MHC Class II
  • HLA-A Antigens / genetics
  • HLA-A Antigens / immunology
  • HLA-B Antigens / genetics
  • HLA-B Antigens / immunology
  • HLA-C Antigens / genetics
  • HLA-C Antigens / immunology
  • Humans
  • Major Histocompatibility Complex*
  • Polymorphism, Genetic*
  • Primates / genetics
  • Primates / immunology*
  • Species Specificity


  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-C Antigens