Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease

Neurology. 2006 Aug 22;67(4):697-9. doi: 10.1212/01.wnl.0000227732.37801.d4. Epub 2006 May 25.

Abstract

LRRK2 G2019S is the most common known cause of Parkinson disease (PD) in patients of European origin, but little is known about its distribution in other populations. The authors identified two of 586 Japanese patients with PD heterozygous for the mutation who shared a haplotype distinct from that observed in Europeans. This suggests that G2019S originated from separate founders in Europe and Japan and is more widely dispersed than previously recognized.

Publication types

  • Controlled Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • DNA Mutational Analysis
  • Female
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Haplotypes / genetics*
  • Humans
  • Japan / epidemiology
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Male
  • Middle Aged
  • Mutation
  • Parkinson Disease / epidemiology*
  • Parkinson Disease / genetics*
  • Prevalence
  • Protein-Serine-Threonine Kinases / genetics*
  • Risk Assessment / methods*
  • Risk Factors
  • Washington / epidemiology

Substances

  • Genetic Markers
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein-Serine-Threonine Kinases