The relationship between mitochondrial shape and function and the cytoskeleton

Biochim Biophys Acta. May-Jun 2006;1757(5-6):692-9. doi: 10.1016/j.bbabio.2006.04.013. Epub 2006 Apr 19.


Mitochondria are crucial organelles for life and death of the cell. They are prominent players in energy conversion and integrated signaling pathways including regulation of Ca2+ signals and apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport at specialized cellular sites. This transport occurs by interactions with a variety of cytoskeletal proteins that also have the ability to influence shape and function of the organelle. A growing body of evidence suggests that mitochondria use cytoskeletal proteins as tracks for their movement; in turn, mitochondrial morphology and function is regulated via mostly uncharacterized pathways, by the cytoskeleton.

Publication types

  • Review

MeSH terms

  • Actin Cytoskeleton / physiology
  • Actin Cytoskeleton / ultrastructure
  • Actins / physiology
  • Animals
  • Cytoskeleton / physiology*
  • Cytoskeleton / ultrastructure
  • Humans
  • Microtubules / physiology
  • Microtubules / ultrastructure
  • Mitochondria / physiology*
  • Mitochondria / ultrastructure
  • Mitochondrial Swelling / physiology
  • Yeasts / metabolism
  • Yeasts / ultrastructure


  • Actins