Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome

Fertil Steril. 2006 Jul;86(1):243-6. doi: 10.1016/j.fertnstert.2005.11.069. Epub 2006 May 30.


Trivalent chromium (1000 microg), as chromium picolinate, given without change in diet or activity level, caused a 38% mean improvement in glucose disposal rate in five obese subjects with polycystic ovary syndrome who were tested with a euglycemic hyperinsulinemic clamp technique. This suggests that chromium picolinate, an over-the-counter dietary product, may be useful as an insulin sensitizer in the treatment of polycystic ovary syndrome.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Female
  • Humans
  • Hyperinsulinism / prevention & control*
  • Insulin Resistance*
  • Iron Chelating Agents / administration & dosage
  • Obesity / drug therapy*
  • Picolinic Acids / administration & dosage*
  • Polycystic Ovary Syndrome / drug therapy*
  • Treatment Outcome


  • Iron Chelating Agents
  • Picolinic Acids
  • picolinic acid