Predictive value of respiratory symptoms and bronchial hyperresponsiveness to diagnose asthma in New Zealand

Respir Med. 2006 Dec;100(12):2107-11. doi: 10.1016/j.rmed.2006.03.028. Epub 2006 May 30.


Respiratory symptoms are often used as the only diagnostic criteria for asthma in epidemiological surveys and the clinical diagnosis of asthma relies primarily on a detailed history. The aim of this study is to predict the diagnostic value of 11 different respiratory symptoms to diagnose asthma, and to determine if bronchial hyperresponsiveness (BHR) improves the predictive value of these respiratory symptoms. A random sample of 1257 subjects aged 20-44 years old in 3 different areas of New Zealand were selected between March 1991 and December 1992 to answer the European Community Respiratory Health Survey questionnaire on respiratory symptoms. Of these, 784 underwent bronchial challenge with methacholine. The prevalence of current doctor diagnosed asthma (DDA) defined as asthma confirmed by a physician and an asthma attack in the last 12 months was 8.3%. Wheezing with dyspnoea is the single best predictor of diagnosed asthma with a sensitivity of 82%, a specificity of 90% and a Youden's index of 0.72. Wheezing alone is more sensitive (94%) but less specific (76%), with a Youden's index of 0.70. The addition of BHR to asthma symptoms decreases sensitivity and increases specificity with a small increase in Youden's index to 0.75. In New Zealand adults, a history of wheezing with BHR best predicts a diagnosis of asthma but wheezing alone or with dyspnoea are the two best symptoms for predicting asthma.

MeSH terms

  • Adult
  • Asthma / diagnosis*
  • Asthma / epidemiology
  • Asthma / physiopathology
  • Bronchial Hyperreactivity / etiology
  • Bronchial Hyperreactivity / physiopathology*
  • Bronchial Provocation Tests / methods
  • Dyspnea / etiology
  • Female
  • Humans
  • Male
  • New Zealand / epidemiology
  • Predictive Value of Tests
  • Prevalence
  • Respiratory Sounds / etiology
  • Sensitivity and Specificity
  • Sex Distribution