P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease

Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. doi: 10.1016/j.bmcl.2006.05.022. Epub 2006 May 30.


Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.

MeSH terms

  • Hepatitis C / enzymology*
  • Macrocyclic Compounds / pharmacology*
  • Serine Proteinase Inhibitors / pharmacology*
  • Viral Nonstructural Proteins / antagonists & inhibitors*
  • X-Ray Diffraction


  • Macrocyclic Compounds
  • NS3 protein, hepatitis C virus
  • Serine Proteinase Inhibitors
  • Viral Nonstructural Proteins