Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products

Ann Thorac Surg. 2006 Jun;81(6):S2367-72. doi: 10.1016/j.athoracsur.2006.02.071.


Conventional neonatal cardiopulmonary bypass requires the use of large volumes of allogeneic blood to prevent unacceptable hemodilution. Evidence is accumulating to suggest that the use of blood products during cardiopulmonary bypass has a negative effect on clinical recovery through inflammatory side effects. This would suggest an advantage for eliminating blood use in infant cardiopulmonary bypass through circuit miniaturization. In this article, we review the data supporting this rationale and provide the results from studies in our laboratory that emphasize the benefits of circuit miniaturization.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Animals
  • Animals, Newborn
  • Blood Component Transfusion / adverse effects
  • Capillary Leak Syndrome / physiopathology
  • Capillary Leak Syndrome / prevention & control
  • Cardiopulmonary Bypass / adverse effects*
  • Cardiopulmonary Bypass / instrumentation
  • Catheters, Indwelling
  • Cytokines / metabolism
  • Equipment Design
  • Filtration
  • Heart Arrest, Induced / instrumentation
  • Humans
  • Infant
  • Infant, Newborn
  • Infusion Pumps
  • Miniaturization
  • Sus scrofa
  • Systemic Inflammatory Response Syndrome / etiology
  • Systemic Inflammatory Response Syndrome / physiopathology
  • Systemic Inflammatory Response Syndrome / prevention & control*
  • Transfusion Reaction


  • Cytokines