Abstract
During 2003-2004, locally presenting pleural empyema cases in children increased 3-fold. Antigen analysis of empyema fluid identified Streptococcus pneumoniae in 27 of 29 cases for whom samples were available and capsular polysaccharide type 1 in 18 of these. Use of a conjugate vaccine without serotype 1 antigen would have had limited impact on this morbidity in our region.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Distribution
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Antibodies, Bacterial / analysis
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Child
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Child, Preschool
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Empyema, Pleural / epidemiology
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Empyema, Pleural / microbiology
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Empyema, Pleural / prevention & control*
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Enzyme-Linked Immunosorbent Assay
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Female
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Follow-Up Studies
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Humans
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Immunity / physiology
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Incidence
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Male
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Pneumococcal Infections / epidemiology
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Pneumococcal Infections / prevention & control*
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Pneumococcal Vaccines / administration & dosage*
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Prospective Studies
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Risk Assessment
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Streptococcus pneumoniae / isolation & purification*
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United Kingdom / epidemiology
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Vaccines, Conjugate / administration & dosage
Substances
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Antibodies, Bacterial
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Pneumococcal Vaccines
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Vaccines, Conjugate